Semax Labs
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Compounded, not FDA-approved

The same molecule is stroke medicine in Moscow and a research chemical in Miami

Semax has been described in peer-reviewed journals as a registered Russian nootropic used to treat ischemic stroke, and in the United States it has no approved product at all: in July 2026 FDA proposed that it not even be allowed into compounded drugs. Both of those are true, and the gap between them is not a conspiracy. It is a translation problem. Of the 206 papers indexed on this peptide, 83 are in Russian and 50 are indexed with an English abstract and nothing else, so most of the evidence cannot be read by the people arguing about it. Exactly one record in the entire literature carries a randomized-controlled-trial tag, and it is a 27-patient motor neuron disease study. Every row in our evidence table is labeled by species, and every human row is labeled by the language it was published in.

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  • 206papers indexed on semax in Europe PMC
  • 83of them published in Russian, which is 40.3 percent of everything written about this peptide
  • 1carries a randomized-controlled-trial tag, and it studied 27 patients with motor neuron disease
  • 26rows in our evidence table, each labeled by species, including 4 documented absences of evidence
  • 41fetch-verified citations, 100.0 percent peer-reviewed or government sources

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Semax nasal spray care, made simple

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Key facts

  • StatusCompounded, not FDA-approved
  • Human half-lifeNot establishedsource
  • Human intranasal bioavailabilityNot establishedsource
  • Human Cmax or AUCNot establishedsource
  • Published human PK studies0source
  • Animal brain access (rat, intranasal)Demonstrated by membrane binding and gene expression change within 1 hoursource
  • Animal effective dose used in mechanism work50 micrograms per kilogram (rat)source
  • In vitro potency, human serum enkephalinase inhibitionIC50 10 micromolarsource
  • ClassSynthetic heptapeptide; ACTH(4-7) fragment extended with Pro-Gly-ProChemical referencesource
  • SequenceMet-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)Chemical referencesource
  • Molecular weight813.9 Da (C37H51N9O10S)Chemical referencesource
  • CAS80714-61-0Chemical referencesource
  • US FDA statusNot approved for any use; on FDA's compounding safety-risks listRegulatory recordsource
  • July 2026 PCACFDA proposed semax NOT be added to the 503A Bulks ListRegulatory recordsource
  • Route in the literatureIntranasal (0.1 and 1 percent solutions); endonasal electrophoresis in ophthalmology studiesReview or guidelinesource
  • Indexed literature206 Europe PMC records; 83 Russian-language (40.3 percent)Analytical studysource
  • English abstract only50 records: the abstract is all a non-Russian reader can readAnalytical studysource
  • Randomized controlled trials1 in the entire literature (27 patients, motor neuron disease, Russian)Analytical studysource
  • Double-blind studies0Absence of evidencesource
  • Meta-analyses and systematic reviews0Absence of evidencesource
  • Registered trials (ClinicalTrials.gov)0Absence of evidencesource
  • Human pharmacokineticsNone publishedAbsence of evidencesource
  • Established human doseNone; published regimens disagree by orders of magnitudeAbsence of evidencesource
  • Russian statusDescribed in peer-reviewed literature as a registered Russian nootropic; registration not verified against the state registerReview or guidelinesource
  • Anti-doping statusUnclear; a 2025 anti-doping review pairs semax with tetracosactide (WADA class S2)Review or guidelinesource

Read the full Semax monograph

Browse by topic

Everything on Semax, organized the way you research it.

Dosing14 articlesEvidence11 articlesSourcing10 articlesSafety9 articlesComparisons7 articles

Free Semax tools

Practical calculators and references, each scoped and sourced.

T-03Semax study dose explorerThe per-compound data component: every semax regimen this site could verify in the published literature, filterable by indication, dose, duration, study design and publication language, each row showing the design the source actually describes and linking to the study. It answers the question a calculator cannot: not how many sprays is a dose, but what was actually given, to whom, in what kind of study, and in what language that study was published.T-04Semax claim graderEnter a claim you have read about semax and see what actually sits behind it: the source, the species it was measured in, the study design, the publication language, and whether the claim outruns its evidence. Built from this site's claims ledger, so every answer is the same one the monograph gives.

All guides

51 in-depth, individually cited guides.

Dosing 14 guides

How to reconstitute semax nasal spray, step by stepHow to reconstitute Semax powder into a usable nasal spray: diluent choice, ratios, sterile technique, storage, and why sourcing matters as much as method.Updated 2026-07-25Read guide →
Semax storage and shelf life: how to store it rightSemax nasal spray needs refrigeration once opened and lasts roughly a few weeks at 2-8°C. Here's what the compounding and stability literature actually supports.Updated 2026-07-25Read guide →
Best time to take Semax peptide: morning timing and dosing windowsMost clinical protocols dose Semax intranasal in the morning. Timing matters less than consistency, but early dosing avoids sleep interference and matches natural cortisol rhythm.Updated 2026-07-24Read guide →
Does semax need to be refrigerated?Unopened Semax vials belong in the fridge. Opened nasal spray is generally used within weeks. Here's what the storage guidance actually depends on.Updated 2026-07-24Read guide →
How long does Semax take to work? Timeline and onset by routeSemax shows effects in 5-20 minutes intranasally, with cognitive changes building over 3-7 days. Route, dose, and outcome type all shift the timeline.Updated 2026-07-24Read guide →
How many mg of Semax a day: dosing protocols and clinical evidenceRussian clinical protocols use 600-18,000 mcg/day. Western use is 200-600 mcg intranasal. What the literature actually shows and what's speculation.Updated 2026-07-24Read guide →
How to take Semax peptide: nasal spray dosing and administrationSemax is used as a nasal spray, typically 300 to 600 mcg per dose, 1 to 2 times daily. Learn administration steps, timing, and what the Russian clinical data says.Updated 2026-07-24Read guide →
Semax cycle length: how long to use and when to take breaksSemax cycle protocols range from 10-30 days in clinical trials. Learn typical on/off schedules, what Russian clinical practice shows, and how to plan breaks.Updated 2026-07-24Read guide →
Semax dosage: clinical ranges, administration, and what the evidence showsSemax dosing ranges from 0.3 to 6 mg/day in clinical studies. How administration route, concentration, and study design shape the data you're working with.Updated 2026-07-24Read guide →
Semax dosage calculator: how to dial in your intranasal doseMost users start at 300 to 600 mcg intranasal twice daily. Calculate Semax spray drops from vial concentration, account for absorption, and adjust safely.Updated 2026-07-24Read guide →
Semax half-life: how long the peptide stays active in your systemSemax has a brain half-life of ~30 minutes and a plasma half-life under 5 minutes. Here's what that means for dosing frequency, onset timing, and duration.Updated 2026-07-24Read guide →
How to inject Semax: subcutaneous and intramuscular protocolsSemax injection protocols: subcutaneous 0.2-1 mg daily, IM 1-5 mg per dose. Most research used intranasal delivery. Russian clinical data, no FDA approval.Updated 2026-07-24Read guide →
Semax injection: reconstitution, dosing, and administration guideSemax injection requires reconstitution with bacteriostatic water, subcutaneous administration at 0.3-1.5 mg/day, and understanding its Russian clinical evidence base.Updated 2026-07-24Read guide →
Semax injection sites: subcutaneous vs intramuscular administrationSemax is typically administered intranasally, but injection studies show subcutaneous and intramuscular routes produce measurable nootropic effects in rats.Updated 2026-07-24Read guide →

Evidence 11 guides

Semax before and after claims: what the evidence showsPeople report sharper focus and faster recall on Semax. Here's what's actually behind those before-and-after claims, and what the research does and doesn't show.Updated 2026-07-25Read guide →
How does Semax work? Mechanisms, neurotrophins, and gene expressionSemax increases BDNF, modulates dopamine and serotonin, and alters gene expression tied to neuroprotection. The evidence base is mostly Russian. Here's what we know.Updated 2026-07-24Read guide →
Semax: Russian nootropic peptide, clinical evidence, and dosingSemax is an ACTH(4-10) analog with decades of Russian clinical use. What the evidence shows, what's still uncertain, and how it's actually dosed.Updated 2026-07-24Read guide →
Semax animal studies vs human evidence: what the data showsMost Semax research is in rodents; human trials are limited and largely Russian-language. We review what each tells you and where gaps remain.Updated 2026-07-24Read guide →
Semax clinical trials: what the evidence actually showsSemax has decades of Russian clinical use but limited Western trials. We review the stroke, cognitive, and neuroprotection data and explain the evidence gap.Updated 2026-07-24Read guide →
Semax human studies: what the clinical evidence actually showsRussian clinical trials span stroke, brain injury, and cognitive function. Western replication is limited. Here's what we know and what's missing.Updated 2026-07-24Read guide →
Semax mechanism of action: what the Russian peptide does in the brainSemax binds BDNF receptors, activates dopamine and serotonin systems, and modulates gene expression after ischemia. The full story from decades of Russian research.Updated 2026-07-24Read guide →
Semax results: what the research shows about this Russian peptideSemax research spans 30+ years in Russian clinical trials, showing neuroprotection after stroke and cognitive effects. Western replication is sparse.Updated 2026-07-24Read guide →
Semax stack with other peptides: what the evidence actually saysRussian studies report Semax combined with Pro-Gly-Pro in stroke models; no published Western data on nootropic stacks. What's known, what's theory, what's risk.Updated 2026-07-24Read guide →
Semax timeline: what to expect week by weekSemax's effects appear in two phases: dopamine/serotonin changes within hours, BDNF and gene expression changes over 5 to 7 days. Here's the evidence.Updated 2026-07-24Read guide →
What does Semax actually do? Evidence from Russian trialsSemax activates brain-derived neurotrophic factor, modulates dopamine and serotonin systems, and regulates hundreds of genes after stroke in animal models. What the Russian literature shows.Updated 2026-07-24Read guide →

Sourcing 10 guides

How to verify semax quality before you buy itNo FDA-approved Semax exists in the US, so purity depends on the vendor. Here's what a COA, batch test, and pharmacy sourcing chain should actually show.Updated 2026-07-25Read guide →
Semax compounding pharmacy vs research supplier: buyer reality checkCompounding pharmacies require a prescription and legal sourcing; research suppliers sell unregulated peptide labeled 'not for human use.' Here's what that actually means.Updated 2026-07-25Read guide →
Semax cost and pricing: what you actually pay in 2026Semax nasal spray typically runs $60 to $150 a bottle in the US grey market. Here's what drives the price, what's a ripoff, and what you're really buying.Updated 2026-07-25Read guide →
Best Semax nasal spray: what the clinical evidence actually saysRussian clinical data spans decades, but no FDA-approved Semax spray exists in the U.S. Here's what you need to know about formulations, evidence quality, and sourcing.Updated 2026-07-24Read guide →
Is Semax FDA approved? What researchers need to know in 2026Semax is not FDA-approved in the US and appears on no federal compounding lists. Russian trials span 30 years. Here's the regulatory reality.Updated 2026-07-24Read guide →
Semax certificate of analysis explained: what to check and whyA certificate of analysis proves peptide identity and purity, but most Semax labs skip the tests that matter. Here's what a real CoA includes and what gets faked.Updated 2026-07-24Read guide →
Is Semax legal in the US? FDA status and what you need to knowSemax is not FDA-approved in the US and exists in a gray area under compounding law. Here's what that means for access, legality, and quality control.Updated 2026-07-24Read guide →
Semax prescription requirements: what you actually need to knowSemax isn't FDA-approved, so there's no standard prescription. Here's how compounding, 503A/503B rules, and provider oversight actually work in the US.Updated 2026-07-24Read guide →
Semax purity and testing: what certificates actually tell youMost Semax vendors show HPLC >98% and skip microbial panels. Learn which tests matter, why Russian pharma-grade differs, and what you can't see on a COA.Updated 2026-07-24Read guide →
Where to buy Semax: sourcing realities for r/nootropicsSemax is not FDA-approved and has no legal U.S. seller. Learn why the Reddit sourcing posts exist, what compounding pharmacies can do, and what the evidence actually says.Updated 2026-07-24Read guide →

Safety 9 guides

Is semax safe? what the research actually showsDecades of Russian clinical use, zero FDA approval, and no Western trials. Here's what's actually known about Semax safety, dosed plainly and cited.Updated 2026-07-25Read guide →
Semax drug interactions: what's known and what isn'tNo formal drug interaction trials exist for Semax. Here's what the mechanistic and Russian clinical literature suggests about real risk, from a safety standpoint.Updated 2026-07-25Read guide →
Semax long term side effects: what the evidence actually showsNo published long-term human safety trials exist for Semax past a few months. Here's what decades of Russian use and animal data do and don't tell us.Updated 2026-07-25Read guide →
Does Semax cause hair loss? What the evidence actually showsNo published study links Semax to hair loss. We review the safety literature, mechanism data, and what Russian clinical trials reported over 30 years.Updated 2026-07-24Read guide →
Semax and athlete drug testing: WADA status and detection riskSemax is not on the WADA Prohibited List as of 2024, but its ACTH-like structure and regulatory ambiguity create detection and compliance risks for competitive athletes.Updated 2026-07-24Read guide →
Semax and blood work: what the research shows and doesn'tNo published human trials document blood marker changes from Semax. Here's what animal studies suggest, why pre-dosing labs matter, and what to monitor.Updated 2026-07-24Read guide →
Semax contraindications: what the Russian clinical data saysSemax lacks FDA approval and Western trials. Russian clinical use reports pregnancy concerns and peptide sensitivity as primary contraindications.Updated 2026-07-24Read guide →
Semax in women: what the evidence shows and what's missingMost Semax research used male rodents. Here's what we know about sex-specific mechanisms, pregnancy safety gaps, and real dosing in women.Updated 2026-07-24Read guide →
Semax side effects: what the clinical record actually showsDecades of Russian clinical use report mild transient irritation in ~5-8% of users. No serious adverse events in peer-reviewed trials. Western replication is absent.Updated 2026-07-24Read guide →

Comparisons 7 guides

Semax vs Adderall: comparing a Russian peptide to prescription ADHD medicationSemax is a neuroprotective peptide from Russia; Adderall is an FDA-approved amphetamine for ADHD. Evidence bases, legal status, and mechanisms differ sharply.Updated 2026-07-24Read guide →
Semax vs Dihexa: mechanisms, evidence quality, and practical useSemax has decades of Russian clinical data; Dihexa has zero human studies. Compare mechanisms, evidence, dosing, and what each peptide actually delivers.Updated 2026-07-24Read guide →
Semax vs modafinil: mechanism, evidence, and practical differencesSemax and modafinil work through entirely different mechanisms, one a peptide with Russian trials, one FDA-approved for wakefulness, and they're not interchangeable.Updated 2026-07-24Read guide →
Semax vs N-acetyl Semax amidate: half-life, potency, and evidenceN-acetyl Semax amidate lasts 3-4x longer than regular Semax but has less published human data. Here's what the research actually shows.Updated 2026-07-24Read guide →
Semax vs noopept: comparing two peptide nootropicsSemax is a synthetic ACTH peptide with Russian clinical trials; noopept is a dipeptide mimetic. Both lack FDA approval. Compare evidence, mechanisms, and legal status.Updated 2026-07-24Read guide →
Semax vs nootropics: comparing the evidence, mechanisms, and gapsSemax is an ACTH(4-10) analog with decades of Russian clinical use. Here's how its neuroprotective and cognitive data compare to racetams, cholinergics, and adaptogens.Updated 2026-07-24Read guide →
Semax vs Selank: comparing two Russian synthetic peptidesSemax and Selank are both Russian synthetic peptides with decades of domestic clinical use but no FDA approval. Here's what the evidence actually shows.Updated 2026-07-24Read guide →

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